p.146 抽出テキスト
セボと比較して多かった。以上より,オピオイドが投与されているにもかかわらず,適切な鎮痛効果が得られていない,がん疼痛(神経障害性疼痛,骨転移による痛み)のある患者に対して,鎮痛補助薬として抗うつ薬の併用を条件付きで推奨する。 【引用文献】1) Kalso E, Tasmuth T, Neuvonen PJ. Amitriptyline effectively relieves neuropathic pain following treatment of breast cancer. Pain 1996;64:293‒302 2) Minotti V, De Angelis V, Righetti E, et al. Double‒blind evaluation of short‒term analgesic efficacy of orally administered diclofenac, diclofenac plus codeine, and diclofenac plus imipramine in chronic cancer pain. Pain 1998;74:133‒7 3) Mercadante S, Arcuri E, Tirelli W, et al. Amitriptyline in neuropathic cancer pain in patients on morphine therapy:a randomized placebo‒controlled, double‒blind crossover study. Tumori 2002;88:239‒42 4) Mishra S, Bhatnagar S, Goyal GN, et al. A comparative efficacy of amitriptyline, gabapentin, and pregabalin in neuropathic cancer pain:a prospective randomized double‒blind placebo‒ controlled study. Am J Hosp Palliat Care 2012;29:177‒82 5) Nishihara M, Arai Y‒CP, Yamamoto Y, et al. Combinations of low‒dose antidepressants and low‒dose pregabalin as useful adjuvants to opioids for intractable, painful bone metastases. Pain Physician 2013;16:E547‒52 6) Banerjee M, Pal S, Bhattacharya B, et al. A comparative study of efficacy and safety of gabapentin versus amitriptyline as coanalgesics in patients receiving opioid analgesics for neuropathic pain in malignancy. Indian J Pharmacol 2013;45:334‒8 7) Xiao Y, Liu J, Huang XE, et al. Clinical study on fluvoxamine combined with oxycodone prolonged‒release tablets in treating patients with moderate to severe cancer pain. Asian Pac J Cancer Prev 2014;15:10445‒9 8) Matsuoka H, Iwase S, Miyaji T, et al. Additive duloxetine for cancer‒related neuropathic pain nonresponsive or intolerant to opioid‒pregabalin therapy:a randomized controlled trial (JORTC‒PAL08). J Pain Symptom Manage 2019;58:645‒53 9) Di C, Xu D. Effect of concomitant administration of oxycontin and amitriptyline on patients with severe cancer pain and depression. Trop J Pharm Res 2019;18:129‒34 III章推奨