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Patient with AR Significant aortic root enlargementa Severe AR Significant AR VSARR Bentall VSARR and AV repair Symptoms AV surgery (Class IIb) Follow-up AV surgery (Class I) TAVI (Class IIb) SAVR AV repair (Class IIa) Eligible for surgeryb LVEF ≤50% or LVESD >50 mm or LVESDi >25 mm/m2 LVEF ≤55% or LVESDi >22 mm/m2 or LVESVi >45 mL/m2 Good tissue quality Team expertise Young patient Good tissue quality Team expertise Young patient Figure 5 Management of patients with aortic regurgitation. AR, aortic regurgitation; AV, aortic valve; LVEF, left ventricular ejection fraction; LVESD, left ventricular end-systolic diameter; LVESDi, left ventricular end-systolic diameter indexed to body surface area; LVESVi, left ventricular end-systolic volume indexed to body surface area; SAVR, surgical aortic valve replacement; TAVI, transcatheter aortic valve replacement; VSARR, valve-sparing aortic root replacement. aIndications for surgery on the root/ascending aorta are described in the 2024 ESC Guidelines for the management of peripheral arterial and aortic diseases.8 bConcomitant replacement of the aortic root or ascending aorta should be considered if the maximal diameter is ≥45 mm and the predicted surgical risk is low. ESC Guidelines 4661 Downloaded from academic.oup.com/eurheartj/article/46/44/4635/8234488 by guest on 07 October 2026