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2025 Focused Update of the 2019 ESC/EAS Guidelines for the management of dyslipidaemias Developed by the task force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) Authors/Task Force Members: François Mach *†, (ESC Chairperson) (Switzerland), Konstantinos C. Koskinas*†, (ESC Chairperson) (Switzerland), Jeanine E. Roeters van Lennep *†, (EAS Chairperson) (Netherlands), Lale Tokgözoğlu , (Task Force Co-ordinator) (Türkiye), Lina Badimon (Spain), Colin Baigent (United Kingdom), Marianne Benn (Denmark), Christoph J. Binder (Austria), Alberico L. Catapano (Italy), Guy G. De Backer (Belgium), Victoria Delgado (Spain), Natalia Fabin (Italy), Brian A. Ference (United Kingdom), Ian M. Graham (Ireland), Ulf Landmesser (Germany), Ulrich Laufs (Germany), Borislava Mihaylova (United Kingdom), Børge Grønne Nordestgaard (Denmark), Dimitrios J. Richter (Greece), Marc S. Sabatine (United States of America), and ESC/EAS Scientific Document Group * Corresponding authors: François Mach, Department of Cardiology, Geneva University Hospital, Geneva, Switzerland. Tel: +41 22 372 71 92, Email: francois.mach@hug.ch; Konstantinos C. Koskinas, Department of Cardiology, Bern University Hospital - INSELSPITAL, University of Bern, Bern, Switzerland. Tel: +41 31 632 50 00, Email: Konstantinos.Koskinas@insel.ch; and Jeanine Roeters van Lennep, Department of Internal Medicine, Erasmus MC Cardiovascular Institute, Erasmus MC University Medical Center, Rotterdam, Netherlands. Tel: +31 (010) 704 0 704, Email: j.roetersvanlennep@erasmusmc.nl † The three Chairpersons contributed equally to the document and are joint corresponding authors. Author/Task Force Member affiliations are listed in author information. ESC Clinical Practice Guidelines (CPG) Committee: listed in the Appendix. ESC subspecialty communities having participated in the development of this document: Associations: Association of Cardiovascular Nursing & Allied Professions (ACNAP), Association for Acute CardioVascular Care (ACVC), European Association of Cardiovascular Imaging (EACVI), European Association of Preventive Cardiology (EAPC), European Association of Percutaneous Cardiovascular Interventions (EAPCI), European Heart Rhythm Association (EHRA), and Heart Failure Association (HFA). Councils: Council for Cardiology Practice, Council on Basic Cardiovascular Science. Working Groups: Adult Congenital Heart Disease, Aorta and Peripheral Vascular Diseases, Atherosclerosis and Vascular Biology, Cardiovascular Pharmacotherapy, Cardiovascular Surgery, Cellular Biology of the Heart, Coronary Pathophysiology and Microcirculation, Development Anatomy and Pathology, Thrombosis. Patient Forum This article is co-published with permission in the European Heart Journal and Atherosclerosis. © The European Society of Cardiology and the European Atherosclerosis Society 2025. All rights reserved. The articles are identical except for stylistic differences in keeping with each journal’s style. Either citation can be used when citing this article. No part of this publication may be reproduced, stored in a retrieval system, transmitted, used for text and data mining, or used for training artificial intelligence, in any form or by any means, without the prior permission in writing of Oxford University Press, or as expressly permitted by law, by license or under terms agreed with the appropriate reprographics rights organization. Inquiries concerning reproduction outside the scope of the above should be sent to the Rights Department, Oxford University Press, at the address above. ESC Guidelines are protected by copyright. As per opt out option under Article 4 §3 of EU Directive 2019/790, the European Society of Cardiology (ESC) reserves all rights to license uses of ESC Guidelines to train or develop generative artificial intelligence (AI) models, large language models or other deep learning or machine learning models. European Heart Journal (2025) 46, 4359–4378 https://doi.org/10.1093/eurheartj/ehaf190 Downloaded from academic.oup.com/eurheartj/article/46/42/4359/8234482 by guest on 07 October 2026