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ARC-HBR Academic Research Consortium for High Bleeding Risk ARNI Angiotensin receptor neprilysin inhibitor ART Antiretroviral therapy ASCVD Atherosclerotic cardiovascular disease ASE American Society of Echocardiography AUGUSTUS Open-Label, 2 × 2 Factorial, Randomized Controlled, Clinical Trial to Evaluate the Safety of Apixaban versus Vitamin K Antagonist and Aspirin versus Aspirin Placebo in Patients with Atrial Fibrillation and Acute Coronary Syndrome or Percutaneous Coronary Intervention BARC Bleeding Academic Research Consortium b.i.d. bis in die (twice daily) BMI Body mass index BP Blood pressure b.p.m. Beats per minute CABG Coronary artery bypass grafting CAC Coronary artery calcification CACS Coronary artery calcium score CACS-CL CACS + risk-factor-weighted clinical likelihood (RF-CL) model CAD Coronary artery disease CANTOS Canakinumab Antiinflammatory Thrombosis Outcome Study CAPRIE Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events CCB Calcium channel blocker CCS Chronic coronary syndrome(s) CCTA Coronary computed tomography angiography CFC Coronary flow capacity CFR Coronary flow reserve CFVR Coronary flow velocity reserve CHA2DS2-VASc Congestive heart failure or left ventricular dysfunction, hypertension, age ≥75 (doubled), diabetes, stroke (doubled), vascular disease, age 65–74, sex category (female) CI Confidence interval CKD Chronic kidney disease CMD Coronary microvascular dysfunction CMR Cardiac magnetic resonance COLCOT Colchicine Cardiovascular Outcomes Trial COMPASS Cardiovascular Outcomes for People Using Anticoagulation Strategies COURAGE Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation CRT Cardiac resynchronization therapy CT Computed tomography CVD Cardiovascular disease CYP2C19 Cytochrome P450 2C19 CYP3A4 Cytochrome P450 3A4 CZT Cadmium–zinc–telluride DAPT Dual antiplatelet therapy DEFINE GPS Distal Evaluation of Functional Performance with Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting DES Drug-eluting stent DEFINE-FLAIR Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation DHP Dihydropyridine DM Diabetes mellitus DOAC Direct oral anticoagulant dPR Diastolic pressure ratio DSE Dobutamine stress echocardiography EACTS European Association for Cardio-Thoracic Surgery EACVI European Association of Cardiovascular Imaging ECG Electrocardiogram EF Ejection fraction eGFR Estimated glomerular filtration rate EMA European Medicines Agency ESC European Society of Cardiology EXCEL Evaluation of XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization FAME Fractional Flow Reserve versus Angiography for Multivessel Evaluation FFR Fractional flow reserve FFR-CT Coronary computed tomography angiography-derived fractional flow reserve FREEDOM Strategies for Multivessel Revascularization in Patients with Diabetes GDMT Guideline-directed medical therapy GI Gastrointestinal GIP Glucose-dependent insulinotropic polypeptide GLOBAL LEADERS

Ticagrelor plus aspirin for 1 month, followed by ticagrelor monotherapy for 23 months vs. aspirin plus clopidogrel or ticagrelor for 12 months, followed by aspirin monotherapy for 12 months after implantation of a drug-eluting stent (DES): a multicentre, open-label, randomized superiority trial GLP-1 Glucagon-like peptide-1 GUSTO Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Arteries HbA1c Glycated haemoglobin HBR High bleeding risk HDL-C High-density lipoprotein cholesterol HF Heart failure HFmrEF Heart failure with mildly reduced ejection fraction HFpEF Heart failure with preserved ejection fraction HFrEF Heart failure with reduced ejection fraction HIV Human immunodeficiency virus HMR Hyperaemic myocardial velocity resistance HOST-EXAM Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis-EXtended Antiplatelet Monotherapy HR Hazard ratio hs-CRP High-sensitivity C-reactive protein HSR Hyperaemic stenosis resistance i.c. Intracoronary i.v. Intravenous ICA Invasive coronary angiography ICD Implantable cardioverter defibrillator ICFT Invasive coronary functional testing iFR Instantaneous wave-free ratio iFR- SWEDEHEART

Instantaneous Wave-free Ratio versus Fractional Flow Reserve in Patients with Stable Angina Pectoris or Acute Coronary Syndrome ILIAS Inclusive Invasive Physiological Assessment in Angina Syndromes IMR Index of microcirculatory resistance INOCA Ischaemia with non-obstructive coronary arteries INR International normalized ratio IQR Interquartile range Downloaded from academic.oup.com/eurheartj/article/45/36/3415/7743115 by guest on 07 October 2026