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Ceftriaxone 4 g/day i.v. in 2 doses Gentamicin 3 mg/kg/day i.v. or i.m. in 1 dose Paediatric antibiotic dosage and route

Amoxicillin 200–300 mg/kg/day i.v. in 4–6 doses, up to maximum of 12 g/day Ampicillin 200–300 mg/kg/day i.v. in 4–6 doses, up to maximum of 12 g/day Ceftriaxone 100 mg/kg i.v. in 2 doses Gentamicin 3 mg/kg/day i.v. or i.m. in 3 equally divided doses In patients with PVE and patients with complicated NVE or >3 months of symptoms due to non-HLAR Enterococcus spp., the combination of ampicillin or amoxicillin with ceftriaxone for 6 weeks or with gentamicin for 2 weeks is recommended using the following doses:

I B

Adult antibiotic dosage and route

Amoxicillin 12 g/day i.v. in 4–6 doses Ampicillin 12 g/day i.v. in 4–6 doses Ceftriaxone 4 g/day i.v. in 2 doses Gentamicin 3 mg/kg/day i.v. or i.m. in 1 dose Paediatric antibiotic dosage and route

Ampicillin 200–300 mg/kg/day i.v. in 4–6 doses, up to maximum of 12 g/day Amoxicillin 200–300 mg/kg/day i.v. in 4–6 doses, up to maximum of 12 g/day Ceftriaxone 100 mg/kg/day i.v. in 2 doses Gentamicin 3 mg/kg/day i.v. or i.m. in 3 equally divided doses High-level aminoglycoside resistance In patients with NVE or PVE due to HLAR Enterococcus spp., the combination of ampicillin or amoxicillin and ceftriaxone for 6 weeks is recommended using the following doses:

I B

Adult antibiotic dosage and route

Ampicillin 12 g/day i.v. in 4–6 doses Amoxicillin 12 g/day i.v. in 4–6 doses Ceftriaxone 4 g/day i.v. or i.m. in 2 doses Paediatric antibiotic dosage and route

Ampicillin 200–300 mg/kg/day i.v. in 4–6 doses, up to maximum of 12 g/day Amoxicillin 200–300 mg/kg/day i.v. in 4–6 doses, up to maximum of 12 g/day Ceftriaxone 100 mg/kg i.v. or i.m. in 2 doses Beta-lactam-resistant Enterococcus spp. (E. faecium) In patients with IE due to beta-lactam-resistant Enterococcus spp. (E. faecium), vancomycin for 6 weeks combined with gentamicin for 2 weeks is recommended using the following doses:

I C

Adult antibiotic dosage and route

Vancomycin 30 mg/kg/day i.v. in 2 doses Gentamicin 3 mg/kg/day i.v. or i.m. in 1 dose Paediatric antibiotic dosage and route

Vancomycin 30 mg/kg/day i.v. in 2–3 equally divided doses Gentamicin 3 mg/kg/day i.v. or i.m. in 1 dose Vancomycin-resistant Enterococcus spp. In patients with IE due to vancomycin-resistant Enterococcus spp., daptomycin combined with beta-lactams (ampicillin, ertapenem, or ceftaroline) or fosfomycin is recommended using the following doses:

I C

Adult antibiotic dosage and route

Daptomycin 10–12 mg/kg/day i.v. in 1 dose Ampicillin 12 g/day i.v. in 4–6 doses Fosfomycin 12 g/day i.v. in 4 doses Ceftaroline 1800 mg/day i.v. in 3 doses Ertapenem 2 g/day i.v. or i.m. in 1 dose Paediatric antibiotic dosage and route

Daptomycin 10–12 mg/kg/day i.v. in 1 dose (age-adjusted) Ampicillin 200–300 mg/kg/day i.v. in 4–6 doses, up to a maximum of 12 g/day Fosfomycin 2–3 g/day i.v. in 1 dose Ceftaroline 24–36 mg/kg/day in 3 doses Ertapenem 1 g/day i.v. or i.m. in 1 dose (if younger than 12 years, 15 mg/kg/dose [to a maximum of 500 mg] twice daily)

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