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Ceftriaxone 2 g/day i.v. in 1 dose Gentamicin 3 mg/kg/day i.v. or i.m. in 1 dose Paediatric antibiotic dosage and route

Penicillin G 200 000 U/kg/day i.v. in 4–6 divided doses Amoxicillin 200–300 mg/kg/day i.v. in 4–6 doses, up to maximum of 12 g/day Ceftriaxone 100 mg/kg i.v. in 1 dose Gentamicin 3 mg/kg/day i.v. or i.m. in 1 dose or 3 equally divided doses Allergy to beta-lactams In patients allergic to beta-lactams and with IE due to oral streptococci and S. gallolyticus, vancomycin for 4 weeks in NVE or for 6 weeks in PVE is recommended using the following doses: I C Adult antibiotic dosage and route

Vancomycin 30 mg/kg/day i.v. in 2 doses Paediatric antibiotic dosage and route

Vancomycin 30 mg/kg/day i.v. in 2 or 3 equally divided doses Oral streptococci and Streptococcus gallolyticus group susceptible, increased exposure or resistant to penicillin In patients with NVE due to oral streptococci and S. gallolyticus, penicillin G, amoxicillin, or ceftriaxone for 4 weeks in combination with gentamicin for 2 weeks is recommended using the following doses:

I B

Adult antibiotic dosage and route

Penicillin G 24 million U/day i.v. either in 4–6 doses or continuously Amoxicillin 12 g/day i.v. in 4–6 doses Ceftriaxone 2 g/day i.v. in 1 dose Gentamicin 3 mg/kg/day i.v. or i.m. in 1 dose In patients with PVE due to oral streptococci and S. gallolyticus, penicillin G, amoxicillin, or ceftriaxone for 6 weeks combined with gentamicin for 2 weeks is recommended using the following doses: I B Adult antibiotic dosage and route

Penicillin G 24 million U/day i.v. either in 4–6 doses or continuously Amoxicillin 12 g/day i.v. in 4–6 doses Ceftriaxone 2 g/day i.v. in 1 dose Gentamicin 3 mg/kg/day i.v. or i.m. in 1 dose Allergy to beta-lactams In patients with NVE due to oral streptococci and S. gallolyticus and who are allergic to beta-lactams, vancomycin for 4 weeks is recommended using the following doses: I C Adult antibiotic dosage and route

Vancomycin 30 mg/kg/day i.v. in 2 doses Paediatric antibiotic dosage and route

Vancomycin 30 mg/kg/day i.v. in 2 doses In patients with PVE due to oral streptococci and S. gallolyticus and who are allergic to beta-lactams, vancomycin for 6 weeks combined with gentamicin for 2 weeks is recommended using the following doses:

I C

Adult antibiotic dosage and route

Vancomycin 30 mg/kg/day i.v. in 2 doses Gentamicin 3 mg/kg/day i.v. or i.m. in 1 dose Paediatric antibiotic dosage and route

Vancomycin 30 mg/kg/day i.v. in 2 doses Gentamicin 3 mg/kg/day i.v. or i.m. in 1 dose Recommendations for antibiotic treatment of infective endocarditis due to Staphylococcus spp. IE caused by methicillin-susceptible staphylococci In patients with NVE due to methicillin-susceptible staphylococci, (flu)cloxacillin or cefazolin is recommended for 4–6 weeks using the following doses:

I B

Adult antibiotic dosage and route

(Flu)cloxacillin 12 g/day i.v. in 4–6 doses Cefazolin 6 g/day i.v. in 3 doses Paediatric antibiotic dosage and route

(Flu)cloxacillin 200–300 mg/kg/day i.v. in 4–6 equally divided doses Cefazolin 100 mg/kg/day i.v. in 3–4 doses, up to maximum of 6 g/day

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