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Document Reviewers: Bernard Iung, (CPG Review Co-ordinator) (France), Bernard Prendergast, (CPG Review Co-ordinator) (United Kingdom), Magdy Abdelhamid (Egypt), Marianna Adamo (Italy), Riccardo Asteggiano (Italy), Larry M. Baddour (Unites States of America), Jelena Čelutkienė (Lithuania), John Chambers (United Kingdom), Jean-Claude Deharo (France), Wolfram Doehner (Germany), Laura Dos Subira (Spain), Xavier Duval (France), Volkmar Falk (Germany), Laurent Fauchier (France), Nuria Fernandez-Hidalgo (Spain), Christian Giske2 (Sweden), Anežka Gombošová (Czechia), Gilbert Habib (France), Borja Ibanez (Spain), Tiny Jaarsma (Sweden), Lars Køber (Denmark), Konstantinos C. Koskinas (Switzerland), Dipak Kotecha (United Kingdom), Ulf Landmesser (Germany), Sandra B. Lauck (Canada), Basil S. Lewis (Israel), Maja-Lisa Løchen (Norway), John William McEvoy (Ireland), Borislava Mihaylova (United Kingdom), Richard Mindham (United Kingdom), Lis Neubeck (United Kingdom), Jens Cosedis Nielsen (Denmark), Jean-François Obadia (France), Agnes A. Pasquet (Belgium), Steffen Petersen (United Kingdom), Eva Prescott (Denmark), Susanna Price (United Kingdom), Amina Rakisheva (Kazakhstan), Archana Rao (United Kingdom), François Rouzet (France), Jonathan Sandoe (United Kingdom), Renate B. Schnabel (Germany), Christine Selton-Suty (France), Lars Sondergaard (Denmark), Martin Thornhill (United Kingdom), Konstantinos Toutouzas (Greece), Nico Van de Veire (Belgium), Isidre Vilacosta (Spain), Christiaan Vrints (Belgium), and Olaf Wendler (United Kingdom)

All experts involved in the development of these guidelines have submitted declarations of interest. These have been compiled in a report and simultaneously published in a supplementary document to the guidelines. The report is also available on the ESC website www.escardio.org/Guidelines

See the European Heart Journal online for supplementary documents that include background information and evidence tables.

Keywords Guidelines • Antibiotics • Cardiac imaging • Cardiac implantable electronic device • Cardiac surgery • Complications • Computed tomography • Congenital heart disease • Diagnosis • Echocardiography • Endocarditis • Infection • Nuclear imaging • Positron emission tomography • Prevention • Prognosis • Prosthetic heart valve • Valve disease

Table of contents

1. Preamble .............................................................................................................. 3953 2. Introduction ....................................................................................................... 3955 2.1. What is new ............................................................................................. 3955 3. Prevention ........................................................................................................... 3959 3.1. Rationale ..................................................................................................... 3959 3.2. Populations at risk of infective endocarditis ............................... 3960 3.3. Situations and procedures at risk .................................................... 3961 3.3.1. Dental procedures ......................................................................... 3961 3.3.2. Non-dental procedures ............................................................... 3961 3.3.3. Cardiac or vascular interventions ............................................ 3962 3.4. Patient education .................................................................................... 3962 4. The Endocarditis Team ................................................................................. 3963 5. Diagnosis .............................................................................................................. 3965 5.1. Clinical features ....................................................................................... 3965 5.2. Laboratory findings ................................................................................ 3966 5.3. Microbiological diagnosis ..................................................................... 3966 5.3.1. Blood culture-positive infective endocarditis ..................... 3966 5.3.2. Blood culture-negative infective endocarditis .................... 3966 5.3.3. Proposed strategy for a microbiological diagnostic algorithm in suspected infective endocarditis ................................. 3967 5.4. Imaging techniques ................................................................................. 3967 5.4.1. Echocardiography ........................................................................... 3967 5.4.2. Computed tomography ............................................................... 3969 5.4.3. Magnetic resonance imaging ...................................................... 3969 5.4.4. Nuclear imaging positron emission tomography/ computed tomography (angiography) and single photon emission tomography/computed tomography ............................... 3970 5.5. Diagnostic criteria .................................................................................. 3971 5.5.1. Modifications for the diagnosis of infective endocarditis 3971 5.5.1.1. Major criteria – microbiology ........................................... 3973 5.5.1.2. Major criteria – imaging ....................................................... 3973 5.5.1.3. Minor criteria ........................................................................... 3974 5.5.1.4. Microbiological criteria ........................................................ 3974 5.5.1.5. Infective endocarditis classification ................................. 3975

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ESC Guidelines                                                                                                                                                                                          3949

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