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Screening results ECG results Systematic screening results Consider repeated screening No definite AF but symptoms or high risk of AF or high risk of ischaemic stroke (CHA2DS2-VASc score >1 in men or >2 in women with diabetes) Suspicion of AF Atrial fibrillation confirmed No atrial fibrillation 12-lead ECG Symptomatic patient e.g. palpitations, dyspnoea Asymptomatic patient Opportunistic screening (e.g. pulse palpation, ECG) (Class I) Yearly opportunistic screening Systematic screening: repeated surface ECG, Holter ECG, patient-activated or wearable device Start treatment with OAC (NOACs preferred over VKA) According to CHA2DS2-VASc score Screening and treatment of AF in patients with diabetes by healthcare professionals Negative Negative Negative Positive Positive Positive Figure 17 Screening for atrial fibrillation in patients with diabetes. AF, atrial fibrillation; CHA2DS2-VASc, Congestive heart failure, Hypertension, Age ≥75 years (2 points), Diabetes mellitus, Stroke or transient ischaemic attack (2 points), Vascular disease, Age 65–74 years, Sex category (female); ECG, electrocardiogram; OAC, oral anticoagulant; NOAC, non-vitamin K antagonist oral anticoagulant; VKA, vitamin K antagonist. ESC Guidelines 4097 Downloaded from academic.oup.com/eurheartj/article/44/39/4043/7238227 by guest on 07 October 2026