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Document-Reviewers: Juhani Knuuti, (CPG Review Coordinator) (Finland), Steen Dalby Kristensen, (CPG Review Coordinator) (Denmark), Victor Aboyans (France), Ingo Ahrens (Germany), Sotiris Antoniou (United Kingdom), Riccardo Asteggiano (Italy), Dan Atar (Norway), Andreas Baumbach (United Kingdom), Helmut Baumgartner (Germany), Michael Böhm (Germany), Michael A. Borger (Germany), Hector Bueno (Spain), Jelena Čelutkienė (Lithuania), Alaide Chieffo (Italy), Maya Cikes (Croatia), Harald Darius (Germany), Victoria Delgado (Spain), Philip J. Devereaux (Canada), David Duncker (Germany), Volkmar Falk (Germany), Laurent Fauchier (France), Gilbert Habib (France), David Hasdai (Israel), Kurt Huber (Austria), Bernard Iung (France), Tiny Jaarsma (Sweden), Aleksandra Konradi (Russian Federation), Konstantinos C. Koskinas (Switzerland), Dipak Kotecha (United Kingdom), Ulf Landmesser (Germany), Basil S. Lewis (Israel), Ales Linhart (Czech Republic), Maja-Lisa Løchen (Norway), Michael Maeng (Denmark), Stéphane Manzo-Silberman (France), Richard Mindham (United Kingdom), Lis Neubeck (United Kingdom), Jens Cosedis Nielsen (Denmark), Steffen E. Petersen (United Kingdom), Eva Prescott (Denmark), Amina Rakisheva (Kazakhstan), Antti Saraste (Finland), Dirk Sibbing (Germany), Jolanta Siller-Matula (Austria), Marta Sitges (Spain), Ivan Stankovic (Serbia), Rob F. Storey (United Kingdom), Jurrien ten Berg (Netherlands), Matthias Thielmann (Germany), and Rhian M. Touyz (Canada/United Kingdom) All experts involved in the development of these guidelines have submitted declarations of interest. These have been compiled in a report and simultaneously published in a supplementary document to the guidelines. The report is also available on the ESC website www.escardio.org/Guidelines

See the European Heart Journal online for supplementary data that include background information and detailed discussion of the data that have provided the basis of the guidelines.

Click here to access the corresponding ESC CardioMed chapters.

Keywords Guidelines • Non-cardiac surgery • Pre-operative cardiac risk assessment • Pre-operative cardiac testing • Biomarkers • Pre-operative coronary artery revascularization • Peri-operative cardiac management • Anti-thrombotic therapy • Peri-operative beta-blockers • Pre-operative treatment of valvular disease • Peri-operative treatment of arrhythmias • Post-operative cardiac surveillance • Peri-operative myocardial injury/infarction

Table of contents

1. Preamble ........................................................................................................ 3832 2. Introduction ................................................................................................. 3834 2.1. What is new ........................................................................................ 3834 2.2. The magnitude of the problem ................................................... 3839 2.3. Change in demographics ................................................................ 3840 2.4. Purpose .................................................................................................. 3840 2.5. The outcomes we want to prevent .......................................... 3841 3. Clinical risk evaluation .............................................................................. 3841 3.1. Surgery-related risk .......................................................................... 3841 3.1.1. Timing of surgery ...................................................................... 3842 3.2. Type of surgical approach ............................................................. 3842 3.2.1. Laparoscopy ................................................................................ 3842 3.2.1.1. Vascular and endovascular procedures ................... 3843 3.2.1.2. Video-assisted non-cardiac surgery ........................... 3843 3.3. Patient-related risk ............................................................................ 3843 3.3.1. Initial assessment ....................................................................... 3843 3.3.1.1. Patients aged ,65 years without a history of cardiovascular disease or cardiovascular risk factors ........ 3843 3.3.1.2. Patients aged ≥65 years or with cardiovascular risk factors .................................................................................................... 3843 3.3.1.3. Patients with established cardiovascular disease . 3844 3.3.2. Patients with murmurs, chest pain, dyspnoea, or peripheral oedema ............................................................................... 3845 3.3.2.1. Murmurs ............................................................................... 3845 3.3.2.2. Chest pain ............................................................................ 3845 3.3.2.3. Dyspnoea .............................................................................. 3845

Disclaimer: The ESC Guidelines represent the views of the ESC and were produced after careful consideration of the scientific and medical knowledge and the evidence available at the time of their publication. The ESC is not responsible in the event of any contradiction, discrepancy, and/or ambiguity between the ESC Guidelines and any other official recommendations or guidelines issued by the relevant public health authorities, particularly in relation to good use of health care or therapeutic strategies. Health professionals are encouraged to take the ESC Guidelines fully into account when exercising their clinical judgment, and in the determination and the implementation of preventive, diagnostic, or therapeutic medical strategies; however, the ESC Guidelines do not override, in any way whatsoever, the individual responsibility of health professionals to make appropriate and accurate decisions in consideration of each patient’s health condition and in consultation with that patient and, where appropriate and/or necessary, the patient’s caregiver. The ESC Guidelines do not exempt health professionals from taking into full and careful consideration the relevant official updated recommendations or guidelines issued by the competent public health authorities, in order to manage each patient’s case in light of the scientifically accepted data pursuant to their respective ethical and professional obligations. It is also the health professional’s responsibility to verify the applicable rules and regulations relating to drugs and medical devices at the time of prescription. © The European Society of Cardiology 2022. All rights reserved. For permissions please e-mail: journals.permissions@oup.com No part of this publication may be reproduced, stored in a retrieval system, transmitted, used for text and data mining, or used for training artificial intelligence, in any form or by any means, without the prior permission in writing of Oxford University Press, or as expressly permitted by law, by license or under terms agreed with the appropriate reprographics rights organization. Inquiries concerning reproduction outside the scope of the above should be sent to the Rights Department, Oxford University Press, at the address above. ESC Guidelines are protected by copyright. As per opt out option under Article 4 §3 of EU Directive 2019/790, the European Society of Cardiology (ESC) reserves all rights to license uses of ESC Guidelines to train or develop generative artificial intelligence (AI) models, large language models or other deep learning or machine learning models.

ESC Guidelines                                                                                                                                                                                     3827

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