p.38 抽出テキスト

Baseline 3 M 6 M 9 M 12 M Every 6–12 M

BP

HbA1c

ECG

ABI

TTE

Physical examinationa

Bosutinib Dasatinib

Nilotinib Ponatinib

Nilotinib Ponatinib Nilotinib Ponatinib

Dasatinib Nilotinib Ponatinib

High and very high risk patients treated with dasatinib or ponatinib

Second and third generationBCR-ABL TKI surveillance protocol

Class 1 Class 1Ia Class 1Ib

Bosutinib Dasatinib

Nilotinib Ponatinib

Nilotinib Ponatinib

Dasatinib Ponatinib Bosutinib

Nilotinib Ponatinib

Lipid profile/

Figure 15 Second- and third-generation breakpoint cluster region–Abelson oncogene locus tyrosine kinase inhibitors surveillance protocol. ABI, ankle– brachial index; BCR-ABL, breakpoint cluster region-Abelson oncogene locus; BP, blood pressure; CV, cardiovascular; ECG, electrocardiogram; HbA1c, glycated haemoglobin; M, months; TKI, tyrosine kinase inhibitors; TTE, transthoracic echocardiography. aCoronary artery calcium scoring can reclassify CV risk upwards and downwards in addition to conventional risk factors, and may be considered in men and women with calculated CV risk around decision thresholds.19 Downloaded from academic.oup.com/eurheartj/article/43/41/4229/6673995 by guest on 07 October 2026