p.51 抽出テキスト

1.2 1.4 1.6 1.7

0.9 1.1 1.3 1.5

1.3 1.4 1.5 1.6

1.6 0.7 0.9 1.0 1.1

0.9 1.1 1.3 1.3

1.1 1.3 1.4 1.5

0.9 1.0 1.2 1.3

1.0 1.2 1.4 1.5

1.2 1.4 1.5 1.6

1.3 1.5 1.7

1.5 1.7 1.8 1.9

0.9 1.0 1.2 1.3

1.1 1.3 1.5 1.6

1.3 1.4 1.6 1.7

1.4 1.6 1.7 1.8

0.9 1.1 1.3 1.4

1.4 1.5 1.8 1.9

1.5 1.7 1.8 1.9

1.1 1.3 1.5 1.6

1.3 1.6 1.7 1.8

1.5 1.7 1.9 2.0

0.9 1.2 1.4 1.5

1.4 1.5 1.7 1.8

1.2 1.4 1.6 1.7

0.6 0.7 0.9 0.9

0.4 0.5 0.6 0.7

0.5 0.6 0.7 0.8

0.9 0.2 0.3 0.3 0.3

0.2 0.3 0.5 0.5

0.4 0.5 0.6 0.6

0.3 0.4 0.4 0.6

0.3 0.5 0.5 0.6

0.5 0.6 0.7 0.7

0.6 0.7 0.9

0.8 1.0 1.1 1.2

0.3 0.4 0.4 0.6

0.4 0.5 0.7 0.7

0.5 0.7 0.8 0.9

0.6 0.8 0.9 1.1

0.4 0.4 0.6 0.6

0.7 0.9 1.1 1.1

0.9 1.0 1.3 1.4

0.5 0.6 0.8 0.8

0.6 0.8 0.9 1.1

0.9 1.1 1.3 1.4

0.5 0.6 0.7 0.8

0.8 0.9 1.1 1.2

0.6 0.7 0.8 0.9

0.8 1.0 1.1 1.3

0.6 0.7 0.9 1.0

0.8 0.9 1.1 1.1

1.2 0.4 0.5 0.6 0.6

0.5 0.6 0.7 0.9

0.7 0.8 1.0 1.0

0.5 0.7 0.7 0.8

0.6 0.8 0.8 1.0

0.8 1.0 1.0 1.1

0.9 1.1 1.3

1.1 1.3 1.4 1.6

0.5 0.7 0.7 0.8

0.7 0.8 1.0 1.1

0.8 1.0 1.2 1.2

1.1 1.2 1.4 1.4

0.6 0.6 0.8 0.9

1.0 1.2 1.3 1.5

1.2 1.4 1.5 1.6

0.7 0.9 1.1 1.2

0.9 1.1 1.3 1.4

1.2 1.4 1.6 1.6

0.6 0.8 0.9 1.0

1.0 1.2 1.4 1.5

0.8 1.0 1.1 1.2

0.6 0.7 0.9 0.9

0.4 0.5 0.6 0.6

0.3 0.4 0.5 0.5

0.7 0.1 0.2 0.3 0.2

0.2 0.2 0.3 0.4

0.2 0.3 0.4 0.4

0.3 0.4 0.5 0.4

0.3 0.4 0.4 0.4

0.4 0.5 0.5 0.6

0.5 0.5 0.7

0.8 0.9 1.0 1.1

0.3 0.4 0.5 0.4

0.4 0.5 0.6 0.6

0.5 0.6 0.7 0.8

0.6 0.7 0.9 0.9

0.3 0.5 0.5 0.6

0.7 0.8 0.9 1.1

0.9 1.0 1.2 1.3

0.4 0.6 0.7 0.8

0.6 0.7 0.8 0.9

0.9 1.1 1.3 1.4

0.5 0.6 0.6 0.8

0.7 0.9 1.1 1.2

0.6 0.7 0.7 0.8

0.3 0.4 0.4 0.4

0.8 0.8 0.9 0.9

0.2 0.2 0.2 0.2

0.2 0.3 0.3 0.3

0.3 0.3 0.4 0.4

0.4 0.4 0.5 0.6

0.5 0.6 0.7 0.7

0.6 0.7 0.8 0.8

0.7 0.8 0.9 1.0

0.9 1.0 1.1 1.1

1.0 1.1 1.2 1.3

1.4 1.2 1.3 1.4

0.5 0.6 0.7 0.8

0.6 0.8 0.9 1.0

0.8 1.0 1.1 1.2

1.0 1.2 1.3

1.4 0.1 0.1 0.2 0.2

0.2 0.2 0.3 0.4

0.0 0.0 0.1 0.1

0.1 0.1 0.1 0.1

0.1 0.1 0.1 0.1

0.0 0.1 0.1 0.1

0.1 0.2 0.2 0.2

0.1 0.2 0.2 0.3

0.2 0.2 0.3 0.2

0.2 0.3 0.3 0.4

0.2 0.4 0.4 0.5

0.5 0.4 0.5 0.6

0.1 0.1 0.2 0.2

0.2 0.2 0.2 0.3

0.2 0.2 0.3 0.4

0.2 0.3 0.5

0.5 0.2 0.3 0.3 0.3

0.4 0.5 0.5 0.5

0.1 0.1 0.1 0.1

0.1 0.1 0.2 0.2

0.2 0.2 0.2 0.3

0.2 0.2 0.3 0.3

0.3 0.4 0.4 0.4

0.3 0.4 0.5 0.5

0.4 0.4 0.5 0.5

0.4 0.5 0.6 0.7

0.5 0.6 0.7 0.7

0.9 0.7 0.8 1.0

0.2 0.3 0.4 0.4

0.3 0.4 0.5 0.6

0.4 0.5 0.6 0.7

0.6 0.6 0.7

0.9 0.1 0.0 0.1 0.1

0.1 0.1 0.1 0.2

0.0 0.1 0.0 0.1

0.1 0.0 0.0 0.1

0.0 0.0 0.0 0.0

0.0 0.0 0.0 0.1

0.0 0.0 0.1 0.1

0.1 0.1 0.1 0.1

0.0 0.1 0.1 0.1

0.1 0.1 0.2 0.2

0.1 0.2 0.2 0.2

0.3 0.2 0.2 0.3

0.0 0.0 0.0 0.1

0.1 0.1 0.2 0.1

0.1 0.2 0.2 0.2

0.2 0.2 0.3

0.3

1.0 1.2 1.4 1.5

1.2 1.4 1.6 1.7

1.4 1.5 1.7 1.8

1.6 1.7 1.9 2.0

0.5 0.6 0.7 0.8

0.6 0.8 0.9 1.0

0.8 0.9 1.1 1.2

0.9 1.1 1.3 1.4

0.6 0.8 0.9 1.0

0.8 1.0 1.1 1.3

1.0 1.2 1.4 1.5

1.3 1.4 1.6 1.7

0.5 0.6 0.7 0.8

0.6 0.8 0.9 1.0

0.8 0.9 1.1 1.3

0.9 1.2 1.4 1.5

160-179 140-159 120-139 100-119 160-179 140-159 120-139 100-119 160-179 140-159 120-139 100-119 160-179 140-159 120-139 100-119 160-179 140-159 120-139 100-119 160-179 140-159 120-139 100-119 160-179 140-159 120-139 100-119 160-179 140-159 120-139 100-119 160-179 140-159 120-139

100-119

160-179

140-159

120-139

100-119 90+

85-89

80-84

75-79

70-74

65-69

60-64

55-59

50-54

45-49

Systolic blood pressure (mmHg) Non-smoking Smoking

Age (y)

LIFE-CVD model CVD-free lifetime gain from 1 mmol/L

LDL-C reduction (in years)

Non-smoking Smoking

Non-HDL cholesterol

Women Men

mmol/L

150 200 250 150 200 250 150 200 250 150 200 250 mg/dL

< 0.5 years 0.5 - 0.9 years 1.0 - 1.4 years 1.5 - 2.0 years

≥2.0 years

160-179 140-159 120-139 100-119 40-44

3.0-3.9 4.0-4.9 5.0-5.9 6.0-6.9 3.0-3.9 4.0-4.9 5.0-5.9 6.0-6.9 3.0-3.9 4.0-4.9 5.0-5.9 6.0-6.9 3.0-3.9 4.0-4.9 5.0-5.9 6.0-6.9

Figure 12 Average years-free-of-cardiovascular disease gained per 1 mmol/L (40 mg/dL) low-density lipoprotein cholesterol reduction in apparently healthy persons. The model is currently validated for low- and moderate-risk countries. Lifetime benefit of 1 mmol/L LDL-C lowering for apparently healthy persons, based on the following risk factors: age, sex, current smoking, SBP, and non-HDL-C. The lifetime benefit is expressed as ‘years of median life expectancy free from myocardial infarction or stroke’ gained from 1 mmol/L LDL-C lowering. For 2 mmol/L LDL-C lowering, the average effect is almost twice as large, and so on. The lifetime benefit is calculated by estimating lifetime CVD risk with the LIFE-CVD model76 multiplied by the HR (0.78) from a meta-analysis of the effect of lipid lowering.22 For individualized estimations of lifetime benefit, this table can be used or the electronic version of LIFE-CVD, assessable via the ESC CVD risk app or https://u-prevent.com/. CVD = cardiovascular disease; ESC = European Society of Cardiology; HDL-C = high-density lipoprotein cholesterol; HR = hazard ratio; LDL-C = low-density lipoprotein cholesterol; LIFE-CVD = LIFEtime-perspective CardioVascular Disease; SBP = systolic blood pressure. Downloaded from academic.oup.com/eurheartj/article/42/34/3227/6358713 by guest on 07 October 2026