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Y Suspected heart failure Echocardiography NT-proBNP ≥ 125 pg/mL or BNP ≥ 35 pg/mL N Y Diagnostic algorithm for heart failure Risk factors Symptoms and/or signs Abnormal ECG or if HF strongly suspected or if NT-proBNP/BNP unavailable Abnormal findings Y Heart failure confirmed Define heart failure phenotype based on LVEF measurement ≤40% (HFrEF) 41–49% (HFmrEF) ≥50% (HFpEF) Determine aetiology and commence treatment Heart failure unlikely Consider other diagnoses N Figure 1 The diagnostic algorithm for heart failure. BNP= B-type natriuretic peptide; ECG= electrocardiogram; HFmrEF= heart failure with mildly reduced ejection fraction; HFpEF= heart failure with preserved ejection fraction; HFrEF= heart failure with reduced ejection fraction; LVEF= left ventricular ejection fraction; NT-proBNP= N-terminal pro-B type natriuretic peptide. The abnormal echocardiographic findings are described in more detail in the respective sections on HFrEF (section 5), HFmrEF (section 7), and HFpEF (section 8). Downloaded from academic.oup.com/eurheartj/article/42/36/3599/6358045 by guest on 07 October 2026