p.65 抽出テキスト

Treprostinil Prostacyclin analogue B Unknown Unknown Inadequate human data • use only if needed Animal data: • rabbits (subcutaneous) at dose higher than RHD: increased incidence of foetal skeletal variations Triamterene Diuretic (potassium- sparing)

C Yes Yes (excretion shown in animal milk)

Inadequate human data Animal data • no foetal harm in rats (at 6 MRHD)

Urapidil Akpga-1-blocker/5- HT1A agonist

- Unknown Unknown Inadequate human data

Vardenafil Phosphodiesterase type 5 inhibitor

B Unknown Yes (in rats) Inadequate human data Animal data: • rats (100 MRHD) and rabbits (20 MRHD): no teratogenicity, embryotoxicity, or foetotoxicity; retarded physical development of pups in rats at 1 (= MRHD) and 8 mg/kg/day

Verapamil oral Calcium channel

blocker (Class IV) C Yes Yesb Well tolerated Animal data:- rabbits (oral, 1.5 RHD): no teratogenicity; rats (oral, 6 RHD): no teratogenicity, but embryocidal, retarded foetal growth and development, and hypotension Verapamil i.v. Calcium channel blocker (Class IV)

C Yes Yesb i.v. use is associated with a greater risk of hypotension and subsequent foetal hypoperfusion • see verapamil oral Vernakalant Antiarrhythmic - Unknown Unknown Inadequate human data Animal data: • rats: malformations (misshapen/absent/fused skull bones including cleft palates, bent radius, bent/misshapen scapula, constricted trachea, absent thyroid, and undescended testes) and increased embryofoetal lethality at exposure levels higher than the single i.v. dose in humans Continued Downloaded from academic.oup.com/eurheartj/article/39/34/3165/5078465 by guest on 07 October 2026