p.64 抽出テキスト

Spironolactone Aldosterone antagonist D Yes Yes (1.2%); milk produc- tion can be reduced

Antiandrogenic effects, oral clefts (first trimester) • inadequate human data Animal data: • mice (dose below the MRHD): no teratogenic or other embryotoxic effects • rabbits (dose approximately MRHD): increased rate of resorption and lower number of live foetuses • rats (200 mg/kg/day): feminization of male foetuses; exposure during late preg- nancy (50/100 mg/kg/day) led to dose-dependent decreases in ventral prostate and seminal vesicle weights in males, and enlarged ovaries and uteri in females Statinsf Lipid-lowering drugs X Yes Unknown Congenital anomalies Tadalafil Phosphodiesterase type 5 inhibitor

B Yes (in rats) Yes (in rats) Inadequate human data Animal data: • rats and mice (up to 11 MRHD): no teratogenicity, embryotoxicity, or foeto- toxicity. One of two studies in rats showed decreased post-natal pup survival (at doses >10 MRHD) Ticagrelor Antiplatelet drug - Unknown Yes (excretion shown in rat milk)

Inadequate human data • not recommended during pregnancy Animal data: • rats: minor developmental anomalies at maternal toxic doses; rabbits: slight delay in hepatic maturity and skeletal development at maternal non-toxic doses • rats/rabbits: slightly reduced maternal body weight, reduced neonatal viability and birth weight with delayed growth Ticlopidine Antiplatelet C Unknown Yes (in rats) Inadequate human data Animal data: • mice (200 mg/kg/day), rats (400 mg/kg/day), and rabbits (up to 100 mg/kg/day): no teratogenic potential Torasemide Diuretic (loop) B Unknown Unknown Inadequate human data • contraindicated Animal data: • no foetotoxicity or teratogenicity in rats (at 15 human dose of 20 mg/day) or rabbits (at 5 human dose of 20 mg/day); decrease in average body weight, increase in foetal resorption, delayed foetal ossification at 4 (rabbits) and 5 (rats) higher doses Continued Downloaded from academic.oup.com/eurheartj/article/39/34/3165/5078465 by guest on 07 October 2026