p.62 抽出テキスト

Procainamide Antiarrhythmic (Class IA)

C Yes Yes • Unknown (limited experience) • No animal data

Propafenone Antiarrhythmic

(Class IC) C Yes Unknown Unknown (limited experience) Animal data: • rabbits (3 MRHD) and rats (6 MRHD): embryotoxic (decreased survival) • rats (1 MRHD): increases in maternal deaths, and reductions in neonatal sur- vival, body weight gain, and physiological development at 4 MRHD Propranolol Beta-blocker (Class II) C Yes Yesb Bradycardia and hypoglycaemia in foetus Animal data: • rats (1 MRHD): embryotoxicity (reduced litter size, increased resorption rates) and toxicity (deaths) • rabbits (5 MRHD): no embryo or neonatal toxicity Quinidine Antiarrhythmic (Class IA)

C Yes Yesb Thrombocytopenia, premature birth, eighth nerve toxicity Ranolazine INa-channel blocker - Unknown Unknown Inadequate human data Animal data: • signs of embryonal and maternal toxicity at doses <400 mg/kg/day (2–2.7 MRHD) in rats and 150 mg/kg/day (1.5–2 MRHD) in rabbits, misshapen ster- nebrae and reduced ossification in offspring; these doses in rats and rabbits were associated with an increased maternal mortality rate Riociguat Guanylate cyclase stimulator

- Unknown Yes (present in rat milk) Contraindicated Animal data: • rats: teratogenic and embryotoxic, increased rate of cardiac ventricular septal defect at 8 MRHD, increased post-implantation loss at 2 MRHD; • rabbits: increased abortions (4 MRHD) and foetal toxicity (13 MRHD) Rivaroxaban Anticoagulant - Yes Yes (data from animals indicate secretion in milk)

Inadequate human data • contraindicated Animal data: • in rats: embryofoetal toxicity (post-implantation loss, retarded/progressed ossifi- cation, and hepatic multiple light-coloured spots), increased incidence of com- mon malformations, and placental changes observed at clinically relevant concentrations; maternal haemorrhagic complications Continued Downloaded from academic.oup.com/eurheartj/article/39/34/3165/5078465 by guest on 07 October 2026