p.60 抽出テキスト

Metolazone Diuretic (thiazide) B Yes Yes Inadequate human data • use only if clearly needed Animal data: • treatment of male rats prior to mating with untreated females: birth weight of offspring was decreased and the pregnancy rate was reduced in dams mated with males from the 10 and 50 mg/kg groups Metoprolol Beta-blocker (Class II) C Yes Yesb Bradycardia and hypoglycaemia in foetus Animal data: • rats: no evidence of teratogenicity Mexiletine Antiarrhythmic

(Class IB) C Yes Yesb Inadequate human data

• foetal bradycardia • use only when benefit outweighs risk Animal data: • rats, mice, and rabbits (4 MRHD): no evidence of teratogenicity or impaired fertility, but increase in foetal resorption

Milrinone Phosphodiesterase inhibitor

C Unknown Unknown Inadequate human data Animal data • in rats/rabbits, no teratogenicity after oral or i.v. application Nadolol Beta-blocker (Class II) C Unknown Yes Foetal bradycardia and hypoglycaemia Animal data: • evidence of embryo- and foetotoxicity was found in rabbits, but not in rats or hamsters, at doses 5–10 MRHD; no teratogenic potential was observed in any of these species Nesiritide Recombinant B-type natriuretic peptide

C Unknown Unknown Inadequate human data • use only when benefit outweighs risk Animal data: Continued Downloaded from academic.oup.com/eurheartj/article/39/34/3165/5078465 by guest on 07 October 2026