p.57 抽出テキスト

Fondaparinux Anticoagulant - Yes (maximum of 10%) Yes (excreted in rat milk) Inadequate human data • use only when benefit outweighs risk Animal data: • studies in rats/rabbits: subcutaneous doses up to 10 mg/kg/day in rats (about 32 RHD based on body surface area) and at subcutaneous doses up to 10 mg/ kg/day in rabbits (about 65 RHD based on body surface area) revealed no evi- dence of impaired fertility or harm to the foetus • should not be prescribed to pregnant women unless clearly necessary (see also discussion in section 11) Furosemide Diuretic (loop) C Yes Well tolerated; milk pro- duction can be reduced

Oligohydramnios • inadequate human data • use only when benefit outweighs risk • monitoring of foetal growth is recommended Animal data: • unexplained maternal deaths and abortions in rabbits (2, 4, and 8 MRHD) • increased incidence and severity of hydronephrosis in mice and rabbits Gemfibrozil Lipid-lowering drug C Yes Unknown Inadequate human data Animal data: • rats: increase in stillborns, slight reduction in pup weight, increased skeletal varia- tions, and, rarely, anophthalmia (0.6 and 2 RHD) • rabbits: decreased litter size (1 and 3 RHD) and increased incidence of parietal bone variations (3 RHD) Glyceryl trinitrate Nitrate C Unknown Unknown Bradycardia, tocolytic Animal data: • rats and rabbits (with nitroglycerin ointment): no teratogenic effects Heparin (low molec- ular weight)

Anticoagulant B No No • Long-term use: less osteoporosis and thrombocytopenia than UFH, increased risk of maternal bleeding (see discussion in section 3 for use during pregnancy) • Human data: retrospective cohort study with 693 live births: no increased risk of major developmental abnormalities Animal data: • rats/rabbits: no evidence of teratogenic effects or foetotoxicity

Heparin (unfractionated)

Anticoagulant B No No Long-term use: less osteoporosis and thrombocytopenia than UFH, increased risk of maternal bleeding (see further discussion in section 3 for use during pregnancy) Continued Downloaded from academic.oup.com/eurheartj/article/39/34/3165/5078465 by guest on 07 October 2026