p.55 抽出テキスト

Disopyramide Antiarrhythmic (Class IA)

C Yes Yesb Uterine contractions • use only when benefit outweighs risk Animal data: • no teratogenicity • decreased implantation sites, decreased pup growth and survival (20 RHD)

Dronedarone Antiarrhythmic (Class III)

- Yes (data from animals; no human data available)

Yes (data from animals; no human data available)

Not recommended: limited human data Animal data: • reproductive toxicity (post-implantation losses, reduced foetal and placental weights, and external, visceral and skeletal malformations)

Edoxaban Anticoagulant - Unknown Animal studies show excretion in breast milk; contraindicated in breastfeeding

Contraindicated: • human data: Hokusai-VTE study: 10 cases with exposure in first trimester, for up to 6 weeks. Results: six live births (four full term and two pre-term), one first trimester spontaneous abortion, and three elective terminations Animal data: • reproductive toxicity (gallbladder variations, increased post-implantation losses (49–65 MRHD) • vaginal haemorrhage at higher doses in rats/rabbits

Enoximone Phosphodiesterase inhibitor

- Unknown Unknown Inadequate human studies • use only if necessary Eplerenone Aldosterone antagonist B Unknown Yes (data from animals;

no human data available) Inadequate human data

• should be used during pregnancy only if clearly needed Animal data: • no teratogenic effects in rats or rabbits (exposures up to 32 and 31 times the human AUC, respectively); • decreased body weight in maternal rabbits • increased rabbit foetal resorptions and post-implantation loss at the highest administered dose Epoprostenol Prostacyclin analogue B Unknown Unknown Inadequate human data Animal data: • no impaired fertility or foetal harm in rats (2.5 RHD) and rabbits (4.8 RHD) Evolocumab Lipid-lowering drug (monoclonal antibody)

- Yes (data in monkeys; no human data available)

Unknown Inadequate human data • not recommended Animal data: • no adverse effects on foetal growth or development in monkeys • reduced T cell-dependent antibody response in monkeys immunized with KLH Continued Downloaded from academic.oup.com/eurheartj/article/39/34/3165/5078465 by guest on 07 October 2026