p.54 抽出テキスト

• treated with >_10 MRHD last trimester through • day 22 of lactation)

• increased post-implantation loss in rabbits (25 MRHD). No developmental toxicity in rabbits at 5 MRHD Clopidogrel Antiplatelet drug B Unknown Yes (secreted in rat milk) No adequate human data Animal data: • no impaired fertility or foetotoxicity in rats (65 MRHD) and rabbits (78 MRHD) Colestipol, cholestyramine

Lipid-lowering drugs C Unknown Yes (lowering fat-soluble vitamins)

May impair absorption of fat-soluble vitamins, e.g. vitamin K ! cerebral bleeding (neonatal)

Dabigatran Anticoagulant - Transplacental passage in ex vivo studies of pla- cental transfer

Unknown No human data • use not recommend during pregnancy unless clearly necessary Animal data: • female fertility: decrease in implantations/increase in pre-implantation loss (plasma exposure five-fold higher compared with patients) • decrease in foetal body weight and embryofoetal viability in rodents (plasma exposure 5- to 10-fold higher compared with patients) • increased maternal bleeding (vaginal/uterine) in rodents Danaparoid Anticoagulant B No No Limited human data Animal data: • no impaired fertility or foetotoxicity in rats (8.7 RHD) and rabbits (6 RHD) Digoxine Cardiac glycoside C Yes Yesb Serum levels unreliable, safe Dihydralazine Vasodilator – Unknown Yes Maternal side effects: reflex tachycardia, headache, tachyphylaxis • lupus-like symptoms (maternal/ foetal) Diltiazem Calcium channel

blocker (Class IV) C No Yesb • possible teratogenic effects • use only when benefit outweighs risk Animal data: • embryo and foetal lethality in mice, rats, and rabbits (4–6 RHD), and abnormalities of the skeleton, heart, retina, and tongue • mice, rats, or rabbits: reductions in early individual pup weights and pup survival, prolonged delivery, and increased incidence of stillbirths Continued Downloaded from academic.oup.com/eurheartj/article/39/34/3165/5078465 by guest on 07 October 2026