p.53 抽出テキスト

Atenolold Beta-blocker (Class II) D Yes Yes Hypospadias (first trimester), birth defects, low birth weight, bradycardia and hypo- glycaemia in foetus (second and third trimesters) Beraprost Prostacyclin analogue - Unknown Unknown No human data Animal data: • no lethal or teratogenic effects in rats (<2.0 mg/kg/day) or rabbits (<1 mg/kg/ day) Bendroflumethiazide Diuretic (thiazide) C Yes Yes Inadequate human data Bisoprolol Beta-blocker (Class II) C Yes Yes Foetal bradycardia and hypoglycaemia Bosentan Endothelin receptor

antagonist X Unknown Unknown Contraindicated

• no human data Animal data: • teratogenic in rats (>_ 60 mg/kg/day; 2 MRHD), malformations of the head, mouth, face, and large blood vessels; increased stillbirths and pup mortality (60/ 300 mg/kg/day; 2 and 10 MRHD) • no birth defects in rabbits (<1500 mg/kg/day) Bumetanide Diuretic (loop) C Unknown Unknown Inadequate human data Animal data: • in rodents, no teratogenicity with oral application • no teratogenic effects with i.v. application (rats/mice: 140 MRHD) • moderate growth retardation and increased incidence of delayed ossification of sternebrae in rats (at 3400 oral MRHD; not seen at 1000 oral MRHD) Cangrelor Antiplatelet drug C Unknown Unknown No human data • Animal data: • no malformations in rat or rabbit, no teratogenicity • foetal growth retardation in rats (at 5 less than the MRHD) • increased incidence of abortion and intrauterine losses, and foetal growth retar- dation in rabbits (12 MRHD) Carvedilol Akpga/besa-blocker C Yes (data from rats; no

human data available) Yes

• (data in rats, increased, no human data) • (increased mortality at 1 week post-par- tum in neonates from rats

No adequate human data • bradycardia and hypoglycaemia in foetus • use only if potential benefit outweighs potential risk Animal data: • increased post-implantation loss, decrease in foetal body weight, and delayed skeletal development in rats (50 MRHD). No developmental toxicity in rats at 10 MRHD Continued Downloaded from academic.oup.com/eurheartj/article/39/34/3165/5078465 by guest on 07 October 2026