p.52 抽出テキスト

Ambrisentan Endothelin receptor antagonist

X Unknown Unknown (contraindi- cated during breastfeeding)

Contraindicated • no human data Animal data: • teratogenic in rats (>_ 15 mg/kg/day) and rabbits (>_ 7 mg/kg/day). In both species, abnormalities of lower jaw, hard/ soft palate, heart and vascular malformation, thymus and thyroid abnormalities, ossification of the basisphenoid bone, dis- placement of the umbilical artery

Amiloride Diuretic (potassium- sparing)

B Yes Yes (secreted in rat milk) Inadequate human data Animal data: • no harm to foetus in teratogenicity studies in rabbits (20 RHD) and mice (25 RHD) • no impaired fertility in rats (20 RHD) • decreased rat pup growth and survival (5 or higher RHD)

Amiodarone Antiarrhythmic

(Class III) D Yes Yes Thyroid insufficiency (9%), hyperthyroidism, goitre, bradycardia, growth retardation,

premature birth ARB (sartans) ARB D Unknown Unknown Contraindicated • renal/tubular dysplasia, oligohydramnios, growth retardation, ossification disorders of skull, lung hypoplasia, contractures, large joints, anaemia, intrauterine foetal death Penicillin, ampicillin, amoxicillin, erythro- mycin, mezlocillin, cephalosporins

Antibiotics B Yes Yes No foetal adverse effects reported

Vancomycin, imipe- nem, rifampicin, teicoplanin

Antibiotics C Unknown Unknown Limited data

Aminoglycosides, qui- nolones tetracyclines

Antibiotics D Unknown Unknown Foetal risk: use only when benefit outweighs risk Apixaban Anticoagulant - Transplacental passage in ex vivo studies of pla- cental transfer

Extensive secretion into rat milk with the parent drug as the major component

No human data: not recommended Animal data: • no direct/indirect reproductive toxicity in animal studies • no foetal malformation in rodents • increased maternal bleeding incidence in rodents Continued Downloaded from academic.oup.com/eurheartj/article/39/34/3165/5078465 by guest on 07 October 2026