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Kusumoto et al 2018 Bradycardia Clinical Practice Guidelines

Circulation. 2019;140:e382–e482. DOI: 10.1161/CIR.0000000000000628 August 20, 2019 e459 CLINICAL STATEMENTS AND GUIDELINES

S4.3.2-7.	 Altschuler H, Fisher JD, Furman S. Significance of isolated H-V interval prolongation in symptomatic patients without documented heart block. Am Heart J. 1979;97:19–26. S4.3.2-8.	 Fujimura O, Yee R, Klein GJ, et al. The diagnostic sensitivity of elec-

trophysiologic testing in patients with syncope caused by transient bradycardia. N Engl J Med. 1989;321:1703–7.

5 BRADYCARDIA ATTRIBUTABLE

TO SND

5.1 Pathology/Pathophysiology/Etiology

of SND

S5.1-1.	 Boyett MR, Honjo H, Kodama I. The sinoatrial node, a heterogeneous pacemaker structure. Cardiovasc Res. 2000;47:658–87. S5.1-2.	 den Hoed M, Eijgelsheim M, Esko T, et al. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet. 2013;45:621–31. S5.1-3.	 Deo R, Nalls MA, Avery CL, et al. Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13 372 participants. Heart Rhythm. 2013;10:401–8. S5.1-4.	 Eijgelsheim M, Newton-Cheh C, Sotoodehnia N, et al. Genomewide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet. 2010;19:3885–94. S5.1-5.	 Holm H, Gudbjartsson DF, Arnar DO, et al. Several common variants modulate heart rate, PR interval and QRS duration. Nat Genet. 2010;42:117–22. S5.1-6.	 Holm H, Gudbjartsson DF, Sulem P, et al. A rare variant in MYH6 is associated with high risk of sick sinus syndrome. Nat Genet. 2011;43:316–20. S5.1-7.	 Mezzano V, Liang Y, Wright AT, et al. Desmosomal junctions are necessary for adult sinus node function. Cardiovasc Res. 2016;111:274–86. S5.1-8.	 Csepe TA, Kalyanasundaram A, Hansen BJ, et al. Fibrosis: a structural modulator of sinoatrial node physiology and dysfunction. Front Physiol. 2015;6:37. S5.1-9.	 Thery C, Gosselin B, Lekieffre J, et al. Pathology of sinoatrial node. Correlations with electrocardiographic findings in 111 patients. Am Heart J. 1977;93:735–40. S5.1-10.	 Lien WP, Lee YS, Chang FZ, et al. The sick sinus syndrome: natural history of dysfunction of the sinoatrial node. Chest. 1977;72: 628–34. S5.1-11.	 Dharod A, Soliman EZ, Dawood F, et al. Association of asymptomatic bradycardia with incident cardiovascular disease and mortality: the multi-ethnic study of atherosclerosis (MESA). JAMA Intern Med. 2016;176:219–27. S5.1-12.	 Gann D, Tolentino A, Samet P. Electrophysiologic evaluation of elderly patients with sinus bradycardia: a long-term follow-up study. Ann Intern Med. 1979;90:24–9. S5.1-13.	 Menozzi C, Brignole M, Alboni P, et al. The natural course of untreated sick sinus syndrome and identification of the variables predictive of unfavorable outcome. Am J Cardiol. 1998;82: 1205–9. S5.1-14.	 Engeseth K, Hodnesdal C, Grundvold I, et al. Temporal reduction in chronotropic index predicts risk of cardiovascular death among healthy middle-aged men: a 28-year follow-up study. J Am Heart Assoc. 5;2016:e004555. S5.1-15.	 Lauer MS, Francis GS, Okin PM, et al. Impaired chronotropic response to exercise stress testing as a predictor of mortality. JAMA. 1999;281:524–9. S5.1-16.	 Byrne EA, Fleg JL, Vaitkevicius PV, et al. Role of aerobic capacity and

body mass index in the age-associated decline in heart rate variability (1985). J Appl Physiol. 1996;81:743–50.

5.2 Clinical Presentation of SND

S5.2-1.	 Nielsen JC, Thomsen PE, Hojberg S, et al. A comparison of single-

lead atrial pacing with dual-chamber pacing in sick sinus syndrome. Eur Heart J. 2011;32:686–96. 5.3 Acute Management of SND

5.3.1 Acute Management of Reversible Causes of SND

S5.3.1-1.	Da Costa D, Brady WJ, Edhouse J. Bradycardias and atrioventricular conduction block. BMJ. 2002;324:535–8. S5.3.1-2.	Alboni P, Baggioni GF, Scarfo S, et al. Role of sinus node artery disease in sick sinus syndrome in inferior wall acute myocardial infarction. Am J Cardiol. 1991;67:1180–4. S5.3.1-3.	Ando G, Gaspardone A, Proietti I. Acute thrombosis of the sinus node artery: arrhythmological implications. Heart. 2003;89:E5. S5.3.1-4.	Rokseth R, Hatle L. Sinus arrest in acute myocardial infarction. Br Heart J. 1971;33:639–42. S5.3.1-5.	Zehender M, Meinertz T, Keul J, et al. ECG variants and cardiac arrhythmias in athletes: clinical relevance and prognostic importance. Am Heart J. 1990;119:1378–91. S5.3.1-6.	Jackson LR 2nd, Rathakrishnan B, Campbell K, et al. Sinus node dysfunction and atrial fibrillation: a reversible phenomenon? Pacing Clin Electrophysiol. 2017;40:442–50. S5.3.1-7.	Pasic M, Musci M, Siniawski H, et al. Transient sinus node dysfunction after the Cox-Maze III procedure in patients with organic heart disease and chronic fixed atrial fibrillation. J Am Coll Cardiol. 1998;32:1040–7. S5.3.1-8.	Shin H, Yozu R, Higashi S, et al. Sinus node function after mitral valve surgery using the superior septal approach. Ann Thorac Surg. 2001;71:587–90. S5.3.1-9.	Cleveland RJ, Nelson RJ, Zeilenga DW, et al. Atrial pacing following open-heart surgery. Arch Surg. 1972;105:26–9. S5.3.1-10.	Peretto G, Durante A, Limite LR, et al. Postoperative arrhythmias after cardiac surgery: incidence, risk factors, and therapeutic management. Cardiol Res Pract. 2014;2014:615987. S5.3.1-11.	Franklin SM, Thihalolipavan S, Fontaine JM. Sinus bradycardia in habitual cocaine users. Am J Cardiol. 2017;119:1611–5. S5.3.1-12.	Ettinger PO, Regan TJ, Oldewurtel HA. Hyperkalemia, cardiac conduction, and the electrocardiogram: a review. Am Heart J. 1974;88:360–71. S5.3.1-13.	Lee G, McGavigan AD, Hillock RJ, et al. A grave case of bradycardia. Pacing Clin Electrophysiol. 2006;29:788–90. S5.3.1-14.	Bolognesi R, Tsialtas D, Bolognesi MG, et al. Marked sinus bradycardia and QT prolongation in a diabetic patient with severe hypoglycemia. J Diabetes Complications. 2011;25:349–51. S5.3.1-15.	Luebbert JJ, Lee FA, Rosenfeld LE. Pacemaker therapy for early and late sinus node dysfunction in orthotopic heart transplant recipients: a single-center experience. Pacing Clin Electrophysiol. 2008;31:1108–12. S5.3.1-16.	Bertolet BD, Eagle DA, Conti JB, et al. Bradycardia after heart transplantation: reversal with theophylline. J Am Coll Cardiol. 1996;28:396–9. S5.3.1-17.	Heinz G, Hirschl M, Buxbaum P, et al. Sinus node dysfunction after orthotopic cardiac transplantation: postoperative incidence and long-term implications. Pacing Clin Electrophysiol. 1992;15:731–7. S5.3.1-18.	Santinelli V, Chiariello M, Clarizia M, et al. Sick sinus syndrome: the role of hypervagotonia. Int J Cardiol. 1984;5:532–5. S5.3.1-19.	Desai JM, Scheinman MM, Strauss HC, et al. Electrophysiologic effects on combined autonomic blockade in patients with sinus node disease. Circulation. 1981;63:953–60. S5.3.1-20.	Thomsen JH, Hassager C, Bro-Jeppesen J, et al. Sinus bradycardia during hypothermia in comatose survivors of out-of-hospital cardiac arrest—a new early marker of favorable outcome? Resuscitation. 2015;89:36–42. S5.3.1-21.	Mattu A, Brady WJ, Perron AD. Electrocardiographic manifestations of hypothermia. Am J Emerg Med. 2002;20:314–26. S5.3.1-22.	Grais IM, Sowers JR. Thyroid and the heart. Am J Med. 2014;127:691–8. S5.3.1-23.	Secher NH, Sander Jensen K, Werner C, et al. Bradycardia during severe but reversible hypovolemic shock in man. Circ Shock. 1984;14:267–74. S5.3.1-24.	Zwillich C, Devlin T, White D, et al. Bradycardia during sleep apnea. Characteristics and mechanism. J Clin Invest. 1982;69:1286–92. S5.3.1-25.	Grmec S, Strnad M, Podgorsek D. Comparison of the character-

istics and outcome among patients suffering from out-of-hospital primary cardiac arrest and drowning victims in cardiac arrest. Int J Emerg Med. 2009;2:7–12.

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