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CLINICAL STATEMENTS AND GUIDELINES

Circulation. 2025;152:e114–e218. DOI: 10.1161/CIR.0000000000001356 September 16, 2025 e155

Table 14.  Commercially Available Antihypertensive Medication Single-Pill Combinations Antihypertensive Medication Class Combination Medication Combination Generic Available Doses Available (in Order of Medication Combination Listed) ACEi or ARB + Thiazide-type diuretic Benazepril + HCTZ Yes 10 mg/12.5 mg

20 mg/12.5 mg 20 mg/25 mg

Captopril + HCTZ Yes 25 mg/15 mg

25 mg/25 mg 50 mg/15 mg 50 mg/25 mg

Enalapril + HCTZ Yes 5 mg/12.5 mg

10 mg/25 mg

Fosinopril + HCTZ Yes 10 mg/12.5 mg

20 mg/12.5 mg

Lisinopril + HCTZ Yes 10 mg/12.5 mg

20 mg/12.5 mg 20 mg/25 mg

Moexipril + HCTZ Yes 7.5 mg/12.5 mg

15 mg/12.5 mg 15 mg/25 mg

Quinapril + HCTZ Yes 10 mg/12.5 mg

20 mg/12.5 mg 20 mg/25 mg

Azilsartan + chlorthalidone No (est. patent expiration 2030) 40 mg/12.5 mg

40 mg/25 mg

Candesartan + HCTZ Yes 16 mg/12.5 mg

32 mg/12.5 mg 32 mg/25 mg

Irbesartan + HCTZ Yes 150 mg/12.5 mg

300 mg/12.5 mg 300 mg/25 mg

Losartan + HCTZ Yes 50 mg/12.5 mg

100 mg/12.5 mg 100 mg/25 mg

Olmesartan + HCTZ Yes 20 mg/12.5 mg

40 mg/12.5 mg 40 mg/25 mg

Telmisartan + HCTZ Yes 40 mg/12.5 mg

80 mg/12.5 mg 80 mg/25 mg

Valsartan + HCTZ Yes 80 mg/12.5 mg

160 mg/12.5 mg 160 mg/25 mg 320 mg/12.5 mg 320 mg/25 mg

ACEi or ARB + Calcium channel blocker Benazepril + amlodipine Yes 10 mg/2.5 mg

10 mg/5 mg 20 mg/5 mg 20 mg/10 mg 40 mg/5 mg 40 mg/10 mg

(Continued )

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