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CLINICAL STATEMENTS AND GUIDELINES Circulation. 2025;151:e771–e862. DOI: 10.1161/CIR.0000000000001309 April 1, 2025 e777 the need to repeat existing guideline recommendations. Some recommendations have been carried forward from previously published guidelines. If unchanged, those recommendations remain current. Any changes to the formatting or content of these recommendations are defined as: • Modified: formatting changes (eg, minor verbiage modifications such as PICO[TS] structure) • Adapted: substantive changes (eg, major adaptations, such as a change in Class of Recommendation [COR], Level of Evidence [LOE], drug, or device classification). Changes are depicted in a footnote below the recommendation tables. 1.5 Class of Recommendation and Level of Evidence The COR indicates the strength of recommendation, encompassing the estimated magnitude and certainty of benefit in proportion to risk. The LOE rates the quality of scientific evidence supporting the intervention on the basis of the type, quantity, and consistency of data from clinical trials and other sources (Table 2).1 Table 1. Associated Publications Title Organization Publication Year (Reference) Guidelines Management of blood cholesterol AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/ AGS/APhA/ASPC/NLA/PCNA 201830 Prevention, detection, evaluation, and management of high blood pressure in adults ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ ASH/ASPC/NMA/PCNA 201831 Primary prevention of cardiovascular disease ACC/AHA 201932 Coronary artery revascularization ACC/AHA/SCAI 20214 Evaluation and diagnosis of chest pain AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR 202133 Prevention of stroke in patients with stroke and transient ischemic attack AHA/ASA 202134 Management of heart failure AHA/ACC/HFSA 202235 Management of patients with chronic coronary disease AHA/ACC/ACCP/ASPC/NLA/PCNA 202336 Diagnosis and management of atrial fibrillation ACC/AHA/ACCP/HRS 202337 Other Relevant Documents Home-based cardiac rehabilitation AHA/ACC/AACVPR 201938 Classification of cardiogenic shock SCAI, endorsed by ACC/AHA/SCCM/STS 201939 Contemporary diagnosis and management of patients with myocardial infarction in the absence of obstructive coronary artery disease AHA 201940 Invasive management of acute myocardial infarction complicated by cardiogenic shock AHA 202141 Mechanical complications of acute myocardial infarction AHA 202142 SHOCK stage classification update SCAI, endorsed by ACC/ACEP/AHA/ESC/ ACVC/ISHLT/ SCCM/STS 202143 Management of patients at risk for and with left ventricular thrombus AHA 202244 Cardiac catheterization laboratory management of the comatose adult patient with an out-of-hospital cardiac arrest AHA 202445 AACVPR indicates American Association of Cardiovascular and Pulmonary Rehabilitation; AAPA, American Academy of Physician Associates (formerly American Academy of Physician Assistants); ABC, Association of Black Cardiologists; ACC, American College of Cardiology; ACCP, American College of Clinical Pharmacy; ACEP, American College of Emergency Physicians; ACPM, American College of Preventive Medicine; ACVC, Association for Acute Cardiovascular Care; ADA, American Diabetes Association; AGS, American Geriatrics Society; AHA, American Heart Association; APhA, American Pharmacists Association; ASA, American Stroke Association; ASCVD, atherosclerotic cardiovascular disease; ASE, American Society of Echocardiography; ASH, American Society of Hypertension; ASPC, American Society for Preventive Cardiology; CHEST, American College of Chest Physicians; ESC, European Society of Cardiology; HFSA, Heart Failure Society of America; HRS, Heart Rhythm Society; ISHLT, International Society for Heart and Lung Transplantation; NLA, National Lipid Association; NMA, National Medical Association; PCNA, Preventive Cardiovascular Nurses Association; SAEM, Society for Academic Emergency Medicine; SCAI, Society for Cardiovascular Angiography and Interventions; SCCM, Society of Critical Care Medicine; SCCT, Society of Cardiovascular Computed Tomography; SCMR, Society for Cardiovascular Magnetic Resonance; SHOCK, Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock trial; and STS, Society of Thoracic Surgery. Downloaded from http://ahajournals.org by on October 7, 2026