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CLINICAL STATEMENTS AND GUIDELINES April 1, 2025 Circulation. 2025;151:e771–e862. DOI: 10.1161/CIR.0000000000001309 e784 Figure 3. Initial Assessment of Patients With Suspected ACS. Colors correspond to Class of Recommendation in Table 2. *Examples of evidence-based CDPs and definition of low, intermediate, and high risk as defined in the 2021 AHA/ACC/Multisociety Chest Pain Guideline. ACS indicates acute coronary syndromes; CDP, clinical decision pathway; cTn, cardiac troponin; hs-cTn, high-sensitivity cardiac troponin; NSTEMI, non–ST-segment elevation myocardial infarction; and STEMI, ST-segment elevation myocardial infarction. Adapted with permission from Gulati et al.13 Copyright 2021 American Heart Association, Inc., and American College of Cardiology Foundation. Downloaded from http://ahajournals.org by on October 7, 2026