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CLINICAL STATEMENTS AND GUIDELINES Circulation. 2025;151:e771–e862. DOI: 10.1161/CIR.0000000000001309 April 1, 2025 e781 patient triage. Specifically, patients should be managed based on the presence or absence of ST-segment elevation (or suspected equivalent) on the 12lead ECG (Table 3 for STEMI electrocardiographic criteria). When possible, electrocardiographic tracings can be transmitted to the PPCI center while en route to help expedite coronary reperfusion upon arrival. Because patients with ACS and evidence of heart failure (HF), ventricular arrhythmias, or cardiogenic shock in the prehospital setting are at highest risk for death, identification of these complications is important with subsequent triage of these patients to a PCI-capable facility when possible (Section 8, “Cardiogenic Shock Management”).14,15 Recommendation-Specific Supportive Text 1 The early acquisition and recording of prehospital 12-lead ECGs by trained personnel is associated with shorter reperfusion times and lower mortality rates from STEMI if this diagnostic information is integrated in patients’ care.1,2,16 Appropriately trained EMS personnel (ie, paramedics) can interpret 12-lead ECGs for the identification of STEMI Figure 2. Types and Classification of Acute Coronary Syndromes. NSTEMI indicates non–ST-segment elevation myocardial infarction; and STEMI, ST-segment elevation myocardial infarction. Illustration by Patrick Lane, ScEYEnce Studios. Copyright 2025 American College of Cardiology Foundation, and the American Heart Association, Inc. Downloaded from http://ahajournals.org by on October 7, 2026