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Circulation Circulation. 2025;151:e771–e862. DOI: 10.1161/CIR.0000000000001309 April 1, 2025 e771 Circulation is available at www.ahajournals.org/journal/circ *Writing committee members are required to recuse themselves from voting on sections to which their specific relationships with industry may apply; see Appendix 1 for detailed information. †ACC/AHA Joint Committee on Clinical Practice Guidelines liaison. ‡Lay stakeholder/patient representative. §Society for Cardiovascular Angiography and Interventions representative. ‖American College of Emergency Physicians representative. ¶ACC/AHA joint staff representative. #National Association of EMS Physicians representative. **ACC/AHA Joint Committee on Performance Measures representative. Peer Review Committee Members and AHA/ACC Joint Committee on Clinical Practice Guidelines Members, see page e833. The American Heart Association requests that this document be cited as follows: Rao SV, O’Donoghue ML, Ruel M, Rab T, Tamis-Holland JE, Alexander JH, Baber U, Baker H, Cohen MG, Cruz-Ruiz M, Davis LL, de Lemos JA, DeWald TA, Elgendy IY, Feldman DN, Goyal A, Isiadinso I, Menon V, Morrow DA, Mukherjee D, Platz E, Promes SB, Sandner S, Sandoval Y, Schunder R, Shah B, Stopyra JP, Talbot AW, Taub PR, Williams MS. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the management of patients with acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2025;151:e771–e862. doi: 10.1161/CIR.0000000000001309 © 2025 by the American College of Cardiology Foundation and the American Heart Association, Inc. CLINICAL PRACTICE GUIDELINES 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines Developed in Collaboration With and Endorsed by the American College of Emergency Physicians, National Association of EMS Physicians, and Society for Cardiovascular Angiography and Interventions Writing Committee Members* Sunil V. Rao, MD, FACC, FSCAI, Chair; Michelle L. O’Donoghue, MD, MPH, FACC, FAHA, Vice Chair; Marc Ruel, MD, MPH, FACC, FAHA, Vice Chair; Tanveer Rab, MD, FACC, MSCAI, JC Liaison†; Jaqueline E. Tamis-Holland, MD, FACC, FAHA, FSCAI, JC Liaison†; John H. Alexander, MD, MHS, FACC, FAHA; Usman Baber, MD, MS, FACC, FSCAI; Heather Baker, EdD‡; Mauricio G. Cohen, MD, FACC, FSCAI; Mercedes Cruz-Ruiz, CHWI‡; Leslie L. Davis, PhD, RN, ANP-BC, FACC, FAHA; James A. de Lemos, MD, FACC, FAHA; Tracy A. DeWald, PharmD, MHS, BCPS-AQ Cardiology; Islam Y. Elgendy, MD, FACC, FAHA, FSCAI; Dmitriy N. Feldman, MD, FACC, FSCAI§; Abhinav Goyal, MD, MHS, FACC, FAHA; Ijeoma Isiadinso, MD, MPH, FACC; Venu Menon, MD, FACC, FAHA; David A. Morrow, MD, MPH, FACC, FAHA; Debabrata Mukherjee, MD, MS, FACC, FAHA, MSCAI; Elke Platz, MD, MS, FACEP; Susan B. Promes, MD, MBA, FACEP‖; Sigrid Sandner, MD, MS; Yader Sandoval, MD, FACC, FSCAI; Rachel Schunder, MA¶; Binita Shah, MD, MS; Jason P. Stopyra, MD, MS#; Amy W. Talbot, MPH¶; Pam R. Taub, MD, FACC; Marlene S. Williams, MD, FACC** Aim: The “2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes” incorporates new evidence since the “2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction” and the corresponding “2014 AHA/ACC Guideline for the Management of Patients With Non–ST- Elevation Acute Coronary Syndromes” and the “2015 ACC/AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction.” The “2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes” and the “2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization” retire and replace, respectively, the “2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease.” Downloaded from http://ahajournals.org by on October 7, 2026