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June 18/25, 2019 Circulation. 2019;139:e1082–e1143. DOI: 10.1161/CIR.0000000000000625 e1082 WRITING COMMITTEE MEMBERS Scott M. Grundy, MD, PhD, FAHA, Chair* Neil J. Stone, MD, FACC, FAHA, Vice Chair* Alison L. Bailey, MD, FACC, FAACVPR† Craig Beam, CRE* Kim K. Birtcher, MS, PharmD, AACC, FNLA‡ Roger S. Blumenthal, MD, FACC, FAHA, FNLA§ Lynne T. Braun, PhD, CNP, FAHA, FPCNA, FNLA‖ Sarah de Ferranti, MD, MPH* Joseph Faiella-Tommasino, PhD, PA-C¶ Daniel E. Forman, MD, FAHA** Ronald Goldberg, MD†† Paul A. Heidenreich, MD, MS, FACC, FAHA‡‡ Mark A. Hlatky, MD, FACC, FAHA* Daniel W. Jones, MD, FAHA§ Donald Lloyd-Jones, MD, SCM, FACC, FAHA* Nuria Lopez-Pajares, MD, MPH§§ Chiadi E. Ndumele, MD, PhD, FAHA* Carl E. Orringer, MD, FACC, FNLA‖‖ Carmen A. Peralta, MD, MAS* Joseph J. Saseen, PharmD, FNLA, FAHA¶¶ Sidney C. Smith Jr, MD, MACC, FAHA* Laurence Sperling, MD, FACC, FAHA, FASPC*** Salim S. Virani, MD, PhD, FACC, FAHA* Joseph Yeboah, MD, MS, FACC, FAHA††† © 2018 by the American Heart Association, Inc., and the American College of Cardiology Foundation. CHOLESTEROL CLINICAL PRACTICE GUIDELINES 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/ AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines Circulation https://www.ahajournals.org/journal/circ ACC/AHA Task Force Members, see page e1123 *ACC/AHA Representative. †AACVPR Representative. ‡ACC/AHA Task Force on Clinical Practice Guidelines Liaison. §Prevention Subcommittee Liaison. ‖PCNA Representative. ¶AAPA Representative. **AGS Representative. ††ADA Representative. ‡‡PM Representative. §§ACPM Representative. ‖‖NLA Representative. ¶¶APhA Representative. ***ASPC Representative. †††ABC Representative. The American Heart Association requests that this document be cited as follows: Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/ APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;139:e1082– e1143. DOI: 10.1161/CIR.0000000000000625. Key Words: AHA Scientific Statements ◼ Guidelines ◼ biomarkers, coronary artery calcium score ◼ pharmacological ◼ cardiovascular disease ◼ cholesterol, LDL-cholesterol ◼ diabetes mellitus ◼ drug therapy ◼ hydroxymethylglutaryl- CoA reductase inhibitors/statins ◼ hypercholesterolemia ◼ lipids ◼ patient compliance ◼ primary prevention ◼ risk assessment ◼ risk reduction discussion ◼ risk treatment discussion, secondary prevention ◼ ezetimibe ◼ proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9) inhibitors Downloaded from http://ahajournals.org by on October 7, 2026